class Akismet_REST_API { /** * Register the REST API routes. */ public static function init() { if ( ! function_exists( 'register_rest_route' ) ) { // The REST API wasn't integrated into core until 4.4, and we support 4.0+ (for now). return false; } register_rest_route( 'akismet/v1', '/key', array( array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_key' ), ), array( 'methods' => WP_REST_Server::EDITABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'set_key' ), 'args' => array( 'key' => array( 'required' => true, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ), array( 'methods' => WP_REST_Server::DELETABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'delete_key' ), ) ) ); register_rest_route( 'akismet/v1', '/settings/', array( array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_settings' ), ), array( 'methods' => WP_REST_Server::EDITABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'set_boolean_settings' ), 'args' => array( 'akismet_strictness' => array( 'required' => false, 'type' => 'boolean', 'description' => __( 'If true, Akismet will automatically discard the worst spam automatically rather than putting it in the spam folder.', 'akismet' ), ), 'akismet_show_user_comments_approved' => array( 'required' => false, 'type' => 'boolean', 'description' => __( 'If true, show the number of approved comments beside each comment author in the comments list page.', 'akismet' ), ), ), ) ) ); register_rest_route( 'akismet/v1', '/stats', array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_stats' ), 'args' => array( 'interval' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_interval' ), 'description' => __( 'The time period for which to retrieve stats. Options: 60-days, 6-months, all', 'akismet' ), 'default' => 'all', ), ), ) ); register_rest_route( 'akismet/v1', '/stats/(?P[\w+])', array( 'args' => array( 'interval' => array( 'description' => __( 'The time period for which to retrieve stats. Options: 60-days, 6-months, all', 'akismet' ), 'type' => 'string', ), ), array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_stats' ), ) ) ); register_rest_route( 'akismet/v1', '/alert', array( array( 'methods' => WP_REST_Server::READABLE, 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'get_alert' ), 'args' => array( 'key' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ), array( 'methods' => WP_REST_Server::EDITABLE, 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'set_alert' ), 'args' => array( 'key' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ), array( 'methods' => WP_REST_Server::DELETABLE, 'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ), 'callback' => array( 'Akismet_REST_API', 'delete_alert' ), 'args' => array( 'key' => array( 'required' => false, 'type' => 'string', 'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ), 'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ), ), ), ) ) ); } /** * Get the current Akismet API key. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_key( $request = null ) { return rest_ensure_response( Akismet::get_api_key() ); } /** * Set the API key, if possible. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function set_key( $request ) { if ( defined( 'WPCOM_API_KEY' ) ) { return rest_ensure_response( new WP_Error( 'hardcoded_key', __( 'This site\'s API key is hardcoded and cannot be changed via the API.', 'akismet' ), array( 'status'=> 409 ) ) ); } $new_api_key = $request->get_param( 'key' ); if ( ! self::key_is_valid( $new_api_key ) ) { return rest_ensure_response( new WP_Error( 'invalid_key', __( 'The value provided is not a valid and registered API key.', 'akismet' ), array( 'status' => 400 ) ) ); } update_option( 'wordpress_api_key', $new_api_key ); return self::get_key(); } /** * Unset the API key, if possible. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function delete_key( $request ) { if ( defined( 'WPCOM_API_KEY' ) ) { return rest_ensure_response( new WP_Error( 'hardcoded_key', __( 'This site\'s API key is hardcoded and cannot be deleted.', 'akismet' ), array( 'status'=> 409 ) ) ); } delete_option( 'wordpress_api_key' ); return rest_ensure_response( true ); } /** * Get the Akismet settings. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_settings( $request = null ) { return rest_ensure_response( array( 'akismet_strictness' => ( get_option( 'akismet_strictness', '1' ) === '1' ), 'akismet_show_user_comments_approved' => ( get_option( 'akismet_show_user_comments_approved', '1' ) === '1' ), ) ); } /** * Update the Akismet settings. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function set_boolean_settings( $request ) { foreach ( array( 'akismet_strictness', 'akismet_show_user_comments_approved', ) as $setting_key ) { $setting_value = $request->get_param( $setting_key ); if ( is_null( $setting_value ) ) { // This setting was not specified. continue; } // From 4.7+, WP core will ensure that these are always boolean // values because they are registered with 'type' => 'boolean', // but we need to do this ourselves for prior versions. $setting_value = Akismet_REST_API::parse_boolean( $setting_value ); update_option( $setting_key, $setting_value ? '1' : '0' ); } return self::get_settings(); } /** * Parse a numeric or string boolean value into a boolean. * * @param mixed $value The value to convert into a boolean. * @return bool The converted value. */ public static function parse_boolean( $value ) { switch ( $value ) { case true: case 'true': case '1': case 1: return true; case false: case 'false': case '0': case 0: return false; default: return (bool) $value; } } /** * Get the Akismet stats for a given time period. * * Possible `interval` values: * - all * - 60-days * - 6-months * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_stats( $request ) { $api_key = Akismet::get_api_key(); $interval = $request->get_param( 'interval' ); $stat_totals = array(); $response = Akismet::http_post( Akismet::build_query( array( 'blog' => get_option( 'home' ), 'key' => $api_key, 'from' => $interval ) ), 'get-stats' ); if ( ! empty( $response[1] ) ) { $stat_totals[$interval] = json_decode( $response[1] ); } return rest_ensure_response( $stat_totals ); } /** * Get the current alert code and message. Alert codes are used to notify the site owner * if there's a problem, like a connection issue between their site and the Akismet API, * invalid requests being sent, etc. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function get_alert( $request ) { return rest_ensure_response( array( 'code' => get_option( 'akismet_alert_code' ), 'message' => get_option( 'akismet_alert_msg' ), ) ); } /** * Update the current alert code and message by triggering a call to the Akismet server. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function set_alert( $request ) { delete_option( 'akismet_alert_code' ); delete_option( 'akismet_alert_msg' ); // Make a request so the most recent alert code and message are retrieved. Akismet::verify_key( Akismet::get_api_key() ); return self::get_alert( $request ); } /** * Clear the current alert code and message. * * @param WP_REST_Request $request * @return WP_Error|WP_REST_Response */ public static function delete_alert( $request ) { delete_option( 'akismet_alert_code' ); delete_option( 'akismet_alert_msg' ); return self::get_alert( $request ); } private static function key_is_valid( $key ) { $response = Akismet::http_post( Akismet::build_query( array( 'key' => $key, 'blog' => get_option( 'home' ) ) ), 'verify-key' ); if ( $response[1] == 'valid' ) { return true; } return false; } public static function privileged_permission_callback() { return current_user_can( 'manage_options' ); } /** * For calls that Akismet.com makes to the site to clear outdated alert codes, use the API key for authorization. */ public static function remote_call_permission_callback( $request ) { $local_key = Akismet::get_api_key(); return $local_key && ( strtolower( $request->get_param( 'key' ) ) === strtolower( $local_key ) ); } public static function sanitize_interval( $interval, $request, $param ) { $interval = trim( $interval ); $valid_intervals = array( '60-days', '6-months', 'all', ); if ( ! in_array( $interval, $valid_intervals ) ) { $interval = 'all'; } return $interval; } public static function sanitize_key( $key, $request, $param ) { return trim( $key ); } } Scientists investigated the effect of four vaccines on antibody production. The best result was shown by Pfizer - Novichok (Moscow) Times
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Scientists investigated the effect of four vaccines on antibody production. The best result was shown by Pfizer

by novichoktimes
November 15, 2021
in THE INSIDER
0
Scientists investigated the effect of four vaccines on antibody production.  The best result was shown by Pfizer

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An international team of Mongolian, American and Canadian scientists investigated the effect of Pfizer, Astrazeneca, Sputnik V and Sinopharm vaccines on antibody titer in a small sample of Mongolians, where all four drugs are registered.

The best result was shown by the Pfizer vaccine, the second place was taken by Astrazeneca, the third – by Sputnik V, the least amount of antibodies was detected in those vaccinated with Sinopharm. Research results published in Cell Host and Microbe.

The researchers evaluated the effectiveness with which antibody-containing blood plasma samples block the binding of the virus model to the ACE2 receptor, through which the virus enters cells.

The reasons for the differences in immune responses between types of vaccines are the subject of research. These are likely to include factors such as the amount of active ingredient in each dose and the interval between receiving the first and second injections, the study authors say.

In the Russian Direct Investment Fund, which is engaged in the supply of “Sputnik V” abroad, a comparison named incorrect, stating that the participants in the study vaccinated with the Russian vaccine were, on average, 10 years older than those vaccinated with other drugs. In addition, according to Russian scientists, antibodies in the study participants were measured after a longer period of time after vaccination.

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