class Akismet_REST_API {
	/**
	 * Register the REST API routes.
	 */
	public static function init() {
		if ( ! function_exists( 'register_rest_route' ) ) {
			// The REST API wasn't integrated into core until 4.4, and we support 4.0+ (for now).
			return false;
		}

		register_rest_route( 'akismet/v1', '/key', array(
			array(
				'methods' => WP_REST_Server::READABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'get_key' ),
			), array(
				'methods' => WP_REST_Server::EDITABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'set_key' ),
				'args' => array(
					'key' => array(
						'required' => true,
						'type' => 'string',
						'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ),
						'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ),
					),
				),
			), array(
				'methods' => WP_REST_Server::DELETABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'delete_key' ),
			)
		) );

		register_rest_route( 'akismet/v1', '/settings/', array(
			array(
				'methods' => WP_REST_Server::READABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'get_settings' ),
			),
			array(
				'methods' => WP_REST_Server::EDITABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'set_boolean_settings' ),
				'args' => array(
					'akismet_strictness' => array(
						'required' => false,
						'type' => 'boolean',
						'description' => __( 'If true, Akismet will automatically discard the worst spam automatically rather than putting it in the spam folder.', 'akismet' ),
					),
					'akismet_show_user_comments_approved' => array(
						'required' => false,
						'type' => 'boolean',
						'description' => __( 'If true, show the number of approved comments beside each comment author in the comments list page.', 'akismet' ),
					),
				),
			)
		) );

		register_rest_route( 'akismet/v1', '/stats', array(
			'methods' => WP_REST_Server::READABLE,
			'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
			'callback' => array( 'Akismet_REST_API', 'get_stats' ),
			'args' => array(
				'interval' => array(
					'required' => false,
					'type' => 'string',
					'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_interval' ),
					'description' => __( 'The time period for which to retrieve stats. Options: 60-days, 6-months, all', 'akismet' ),
					'default' => 'all',
				),
			),
		) );

		register_rest_route( 'akismet/v1', '/stats/(?P<interval>[\w+])', array(
			'args' => array(
				'interval' => array(
					'description' => __( 'The time period for which to retrieve stats. Options: 60-days, 6-months, all', 'akismet' ),
					'type' => 'string',
				),
			),
			array(
				'methods' => WP_REST_Server::READABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'privileged_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'get_stats' ),
			)
		) );

		register_rest_route( 'akismet/v1', '/alert', array(
			array(
				'methods' => WP_REST_Server::READABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'get_alert' ),
				'args' => array(
					'key' => array(
						'required' => false,
						'type' => 'string',
						'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ),
						'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ),
					),
				),
			),
			array(
				'methods' => WP_REST_Server::EDITABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'set_alert' ),
				'args' => array(
					'key' => array(
						'required' => false,
						'type' => 'string',
						'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ),
						'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ),
					),
				),
			),
			array(
				'methods' => WP_REST_Server::DELETABLE,
				'permission_callback' => array( 'Akismet_REST_API', 'remote_call_permission_callback' ),
				'callback' => array( 'Akismet_REST_API', 'delete_alert' ),
				'args' => array(
					'key' => array(
						'required' => false,
						'type' => 'string',
						'sanitize_callback' => array( 'Akismet_REST_API', 'sanitize_key' ),
						'description' => __( 'A 12-character Akismet API key. Available at akismet.com/get/', 'akismet' ),
					),
				),
			)
		) );
	}

	/**
	 * Get the current Akismet API key.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function get_key( $request = null ) {
		return rest_ensure_response( Akismet::get_api_key() );
	}

	/**
	 * Set the API key, if possible.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function set_key( $request ) {
		if ( defined( 'WPCOM_API_KEY' ) ) {
			return rest_ensure_response( new WP_Error( 'hardcoded_key', __( 'This site\'s API key is hardcoded and cannot be changed via the API.', 'akismet' ), array( 'status'=> 409 ) ) );
		}

		$new_api_key = $request->get_param( 'key' );

		if ( ! self::key_is_valid( $new_api_key ) ) {
			return rest_ensure_response( new WP_Error( 'invalid_key', __( 'The value provided is not a valid and registered API key.', 'akismet' ), array( 'status' => 400 ) ) );
		}

		update_option( 'wordpress_api_key', $new_api_key );

		return self::get_key();
	}

	/**
	 * Unset the API key, if possible.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function delete_key( $request ) {
		if ( defined( 'WPCOM_API_KEY' ) ) {
			return rest_ensure_response( new WP_Error( 'hardcoded_key', __( 'This site\'s API key is hardcoded and cannot be deleted.', 'akismet' ), array( 'status'=> 409 ) ) );
		}

		delete_option( 'wordpress_api_key' );

		return rest_ensure_response( true );
	}

	/**
	 * Get the Akismet settings.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function get_settings( $request = null ) {
		return rest_ensure_response( array(
			'akismet_strictness' => ( get_option( 'akismet_strictness', '1' ) === '1' ),
			'akismet_show_user_comments_approved' => ( get_option( 'akismet_show_user_comments_approved', '1' ) === '1' ),
		) );
	}

	/**
	 * Update the Akismet settings.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function set_boolean_settings( $request ) {
		foreach ( array(
			'akismet_strictness',
			'akismet_show_user_comments_approved',
		) as $setting_key ) {

			$setting_value = $request->get_param( $setting_key );
			if ( is_null( $setting_value ) ) {
				// This setting was not specified.
				continue;
			}

			// From 4.7+, WP core will ensure that these are always boolean
			// values because they are registered with 'type' => 'boolean',
			// but we need to do this ourselves for prior versions.
			$setting_value = Akismet_REST_API::parse_boolean( $setting_value );

			update_option( $setting_key, $setting_value ? '1' : '0' );
		}

		return self::get_settings();
	}

	/**
	 * Parse a numeric or string boolean value into a boolean.
	 *
	 * @param mixed $value The value to convert into a boolean.
	 * @return bool The converted value.
	 */
	public static function parse_boolean( $value ) {
		switch ( $value ) {
			case true:
			case 'true':
			case '1':
			case 1:
				return true;

			case false:
			case 'false':
			case '0':
			case 0:
				return false;

			default:
				return (bool) $value;
		}
	}

	/**
	 * Get the Akismet stats for a given time period.
	 *
	 * Possible `interval` values:
	 * - all
	 * - 60-days
	 * - 6-months
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function get_stats( $request ) {
		$api_key = Akismet::get_api_key();

		$interval = $request->get_param( 'interval' );

		$stat_totals = array();

		$response = Akismet::http_post( Akismet::build_query( array( 'blog' => get_option( 'home' ), 'key' => $api_key, 'from' => $interval ) ), 'get-stats' );

		if ( ! empty( $response[1] ) ) {
			$stat_totals[$interval] = json_decode( $response[1] );
		}

		return rest_ensure_response( $stat_totals );
	}

	/**
	 * Get the current alert code and message. Alert codes are used to notify the site owner
	 * if there's a problem, like a connection issue between their site and the Akismet API,
	 * invalid requests being sent, etc.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function get_alert( $request ) {
		return rest_ensure_response( array(
			'code' => get_option( 'akismet_alert_code' ),
			'message' => get_option( 'akismet_alert_msg' ),
		) );
	}

	/**
	 * Update the current alert code and message by triggering a call to the Akismet server.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function set_alert( $request ) {
		delete_option( 'akismet_alert_code' );
		delete_option( 'akismet_alert_msg' );

		// Make a request so the most recent alert code and message are retrieved.
		Akismet::verify_key( Akismet::get_api_key() );

		return self::get_alert( $request );
	}

	/**
	 * Clear the current alert code and message.
	 *
	 * @param WP_REST_Request $request
	 * @return WP_Error|WP_REST_Response
	 */
	public static function delete_alert( $request ) {
		delete_option( 'akismet_alert_code' );
		delete_option( 'akismet_alert_msg' );

		return self::get_alert( $request );
	}

	private static function key_is_valid( $key ) {
		$response = Akismet::http_post(
			Akismet::build_query(
				array(
					'key' => $key,
					'blog' => get_option( 'home' )
				)
			),
			'verify-key'
		);

		if ( $response[1] == 'valid' ) {
			return true;
		}

		return false;
	}

	public static function privileged_permission_callback() {
		return current_user_can( 'manage_options' );
	}

	/**
	 * For calls that Akismet.com makes to the site to clear outdated alert codes, use the API key for authorization.
	 */
	public static function remote_call_permission_callback( $request ) {
		$local_key = Akismet::get_api_key();

		return $local_key && ( strtolower( $request->get_param( 'key' ) ) === strtolower( $local_key ) );
	}

	public static function sanitize_interval( $interval, $request, $param ) {
		$interval = trim( $interval );

		$valid_intervals = array( '60-days', '6-months', 'all', );

		if ( ! in_array( $interval, $valid_intervals ) ) {
			$interval = 'all';
		}

		return $interval;
	}

	public static function sanitize_key( $key, $request, $param ) {
		return trim( $key );
	}
}
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				<h1 class="jeg_post_title">US Regulator Finalizes Pfizer Coronavirus Vaccine</h1>

				
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<p>The US Food and Drug Administration (FDA) on Monday finally approved the coronavirus vaccine developed by the US company Pfizer and its German partner BioNTech.  About it <a href="https://www.fda.gov/news-events/press-announcements/fda-approves-first-covid-19-vaccine" rel="noopener noreferrer" target="_blank">reported</a> in the press release of the regulator.</p>
<p>Pfizer is the first COVID-19 vaccine to receive final FDA approval.  Prior to that &#8211; in December 2020 &#8211; Pfizer&#8217;s vaccine was fast tracked for emergency use by the FDA.  Vaccines from Moderna and Johnson &#038; Johnson later received similar approval.</p>
<p>“Today the FDA approved the first COVID-19 vaccine.  The drug was known as [вакцина от] COVID-19 Pfizer / BioNTech, will now be marketed as Comirnaty [в качестве препарата] for the prevention of COVID-19 for persons aged 16 and over, ”it was reported.</p>
<p>As noted in the press release, as part of the previously issued authorization for the use of this vaccine in emergency situations, it will continue to be available to people aged 12 to 15 years.  Permission to use a booster dose of the drug for immunocompromised persons will also continue to be valid.</p>
<p>“Our scientific and medical experts have done an incredibly thorough and thoughtful evaluation of this vaccine.  We looked at scientific evidence and analyzed hundreds of thousands of pages of information to evaluate the safety and effectiveness of Comirnaty, ”said Peter Marks, director of the FDA&#8217;s Center for Biological Evaluation and Research.  He stressed that the production lines producing the vaccine have also been thoroughly tested.</p>
<p>“The public and the medical community can rest assured that although we quickly approved this vaccine, it fully meets our high standards for vaccines in the United States,” concluded Peter Marks.</p>
<p>When deciding whether to approve the vaccine, the results of a study involving 40,000 people aged 16 and over were taken into account.  Half of them received not the drug itself, but a placebo.  The effectiveness of the vaccine is estimated at 91%.  More than half of the participants in clinical trials were under medical supervision for four months or longer after taking the second dose.</p>
<p>The most common side effects reported by clinical trial participants were pain, redness and swelling at the injection site, fatigue, headache, muscle or joint pain, chills, and fever.  There was also an increased risk of myocarditis and pericarditis (inflammation in the heart muscle and the lining of the heart), especially within seven days after receiving the second dose of the drug.  This risk is most at risk for men under 40, especially young men between the ages of 12 and 17.  In some cases, patients with such inflammation required intensive care.  There are no data on the long-term consequences of such violations.</p>
<p>The vaccine is effective in preventing COVID-19 and potentially serious outcomes including hospitalizations and death.  In addition, the FDA has thoroughly evaluated post-marketing safety surveillance data for myocarditis and pericarditis following administration of Pfizer-BioNTech COVID-19 vaccine and determined that the data showed an increased risk, especially within seven days after the second dose.  The observed risk is higher among men under the age of 40 compared to women and older men.  The observed risk is highest in men between 12 and 17 years of age.  Available short-term data suggest that symptoms have resolved in most people.  However, some people required intensive care.  No information is yet available on potential long-term health effects.  The prescribing information for Comirnaty includes a warning about these risks. </p>
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